On her 2005 Affirmation Tour, Beverley performed the song to great critical acclaim and her fans along with Ronnie Wood, which encouraged her to make a studio recording of the song. Piece of My Heart was the lead single from her 2006 best-of compilation Voice – The Best of Beverley Knight. It peaked inside the top ten of the UK radio airplay chart. The physical single was released on March 13, 2006. Due to a change in the UK chart rules which allowed singles to chart purely on downloads a week before their physical release, "Piece of My Heart" entered the UK chart at number ninety-three, becoming one of the first singles to do so. It ranked at number sixteen after its physical commercial release. It was her first single to be released as a DVD. It is her longest-running single to date on the UK Singles Chart, spending eleven weeks inside the top seventy-five. It was her thirteenth top forty entry and her seventh top twenty hit on the UK Singles Chart.